Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-4520 | 4520-2566 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 78 |
| 2 | NRTI | 186 |
| 3 | 3TC+ AZT | 8 |
| 4 | 3TC+ D4T+ IDV | 81 |
| 5 | 3TC+ AZT+ IDV | 61 |
| 6 | DDI+ D4T+ NFV+ EFV | 24 |
| 7 | NFV+ EFV | 1 |
| 8 | EFV | 2 |
| 9 | Unknown | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, N37D, K45R, I62V, L63T, C67S, V77I, I93L |
| >4520-2566| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPRMIGGIGGFIKVRQYD QVTIEISGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| I37F, V60VI, I135T, I178M, Q207K, R211S, A272P |
| >4520-2566| codons 33-273 ALVEFCTEMEKEGKISKIGPENPYNTPIFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQL GIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQG WKGSPAIFQSSMTKILEPFRKQNPDMVIYQYMDDLYVGSDLEIGQHRTKIEELRKHLLSW GFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYP G |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |