Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-4003 | 4003-4055 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 171 |
| 2 | 3TC+ AZT | 22 |
| 3 | 3TC+ D4T | 16 |
| 4 | 3TC+ SQV | 38 |
| 5 | 3TC+ DDC+ NFV+ NVP | 24 |
| 6 | 3TC+ DDI+ EFV+ NFV | 32 |
| 7 | 3TC+ D4T | 18 |
| 8 | 3TC | 2 |
| 9 | 3TC+ DDI+ EFV+ NFV | 14 |
| 10 | 3TC+ DDI+ EFV+ NFV | 14 |
| 11 | 3TC+ EFV+ NFV | 38 |
| 12 | 3TC | 2 |
| 13 | 3TC+ ABC+ RTV+ APV | 5 |
| 14 | 3TC+ ABC+ RTV+ APV+ AZT | 14 |
| 15 | RTV+ APV+ 3TC+ AZT | 28 |
| 16 | APV+ 3TC+ AZT | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | V179D | K103R, D121H, K122E, A158S, F214L |
| >4003-4055| codons 21-260 VKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL NKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLHEDFRKYTAFTIPSINNETP GIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIDIYQYVDDLYVGSDLEIGQHRT KIEELRQHLLRWGLYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, L19I, K20KR, I64V, I72M, T74TA |
| >4003-4055| codons 1-99 PQITLWQRPLVTIKVGGQIREALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAMGAVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |