<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
SWC-4003 4003-4055 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ DDC 171
2 3TC+ AZT 22
3 3TC+ D4T 16
4 3TC+ SQV 38
5 3TC+ DDC+ NFV+ NVP 24
6 3TC+ DDI+ EFV+ NFV 32
7 3TC+ D4T 18
8 3TC 2
9 3TC+ DDI+ EFV+ NFV 14
10 3TC+ DDI+ EFV+ NFV 14
11 3TC+ EFV+ NFV 38
12 3TC 2
13 3TC+ ABC+ RTV+ APV 5
14 3TC+ ABC+ RTV+ APV+ AZT 14
15 RTV+ APV+ 3TC+ AZT 28
16 APV+ 3TC+ AZT 8

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, T215Y     V179D K103R, D121H, K122E, A158S, F214L  
>4003-4055| codons 21-260
VKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL
NKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLHEDFRKYTAFTIPSINNETP
GIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIDIYQYVDDLYVGSDLEIGQHRT
KIEELRQHLLRWGLYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, L19I, K20KR, I64V, I72M, T74TA  
>4003-4055| codons 1-99
PQITLWQRPLVTIKVGGQIREALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILVEICGHKAMGAVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003