Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-3834 | 3834-1270 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ DDC+ IDV | 38 |
| 2 | RTV+ SQV | 17 |
| 3 | DDI+ NFV+ NVP | 38 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10I, T12K, L19I, E35D, M36I, N37E, I62V, L63C, I93L, C95F |
| >3834-1270| codons 1-99 PQITLWQRPIVKIKIGGQIKEALLDTGADDTVLEDIELPGRWKPKIIGGIGGFVKVRQYD QVCIEICGHKAIGTVLVGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V | K103N, Y181C | V35L, R83K, K122Q, I178L, T200A, Q207E, R211K, V245L |
| >3834-1270| codons 21-260 VKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFREL NKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDQDFRKYTAFTIPSINNETP GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVICQYMDDLYVGSDLEIGQHRA KIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPILLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |