<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
SWC-3834 3834-1270 U.S. 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ DDC+ IDV 38
2 RTV+ SQV 17
3 DDI+ NFV+ NVP 38

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M   L10I, T12K, L19I, E35D, M36I, N37E, I62V, L63C, I93L, C95F  
>3834-1270| codons 1-99
PQITLWQRPIVKIKIGGQIKEALLDTGADDTVLEDIELPGRWKPKIIGGIGGFVKVRQYD
QVCIEICGHKAIGTVLVGPTPANIIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V   K103N, Y181C   V35L, R83K, K122Q, I178L, T200A, Q207E, R211K, V245L  
>3834-1270| codons 21-260
VKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFREL
NKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDQDFRKYTAFTIPSINNETP
GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVICQYMDDLYVGSDLEIGQHRA
KIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPILLPEKDSWTVNDIQKL

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005