Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-3714 | 3714-3118 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT | 8 |
| 2 | AZT+ 3TC+ RTV | 10 |
| 3 | AZT+ 3TC+ RTV+ IDV | 34 |
| 4 | 3TC+ RTV+ IDV+ SQV+ D4T | 15 |
| 5 | RTV+ IDV+ SQV+ D4T | 15 |
| 6 | DDI+ NFV+ NVP+ IDV | 18 |
| 7 | 3TC+ AZT+ IDV | 3 |
| 8 | 3TC+ SQV+ D4T | 44 |
| 9 | EFV+ NFV+ DDI | 28 |
| 10 | ABC+ APV+ D4T | 4 |
| 11 | 3TC+ APV+ D4T | 40 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | Y181I | V108I | I37F, E44D, V118I, K122E, I135V, E138G, S162C, I178M, V179I, V189I, T200A, Q207E, R211K |
| >3714-3118| codons 21-260 VKQWPLTEEKIKALVEFCTELEKDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFREL NKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSVNNGTP GIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMIIIQYVDDLYIGSDLEIGQHRA KIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50V, I54V, L90M | G73T, L89V | L10I, K20R, E35D, M36I, L63P, H69K, A71I, I93L |
| >3714-3118| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPKMIGGVGGFVKVRQYD QIPIEICGKKIITTVLVGPTPVNIIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |