Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-3395 | 3395-2365 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 6 |
| 2 | NRTI | 24 |
| 3 | 3TC+ AZT+ IDV | 51 |
| 4 | D4T+ RTV+ SQV | 30 |
| 5 | D4T+ DDI+ NFV+ NVP | 4 |
| 6 | 3TC+ D4T+ DDI+ NFV | 42 |
| 7 | DDI+ NFV+ D4T+ 3TC | 33 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, V82F, L90M | L10LI, L19I, E35D, N37D, L63P, I64IV, A71AT, V77I, I93L |
| >3395-2365| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFVKVRQYD QIPVEICGHKTIGTVLIGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K122E, T165L, K173T, I178M, R211K, V245Q, A272P | E89EG, G213R |
| >3395-2365| codons 21-273 VKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL NKRTQDFWGVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETP GIRYQYNVLPQGWKGSPAIFQSSMLKILEPFRTQNPDMVIYQYVDDLYVGSDLEIGQHRT KIEELRQHLWKWRFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIQLPEKDSWTVNDIQKL VGKLNWASQIYPG |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |