Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-3386 | 3386-2073 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T+ RTV | 42 |
| 2 | RTV | 13 |
| 3 | NVP+ RTV+ SQV | 7 |
| 4 | RTV+ SQV | 1 |
| 5 | RTV | 5 |
| 6 | Unknown | 61 |
| 7 | ABC+ EFV | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, L74V | K103N, Y181C, G190A | A98G | A158S, T165I, T200V, E248X, Q269X, A272P |
| >3386-2073| codons 23-273 QWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKRKDSTKWRKVVDFRELNK RTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGI RYQYNVLPQGWKGSPSIFQSSMIKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRVKI EELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPXKDSWTVNDIQKLVG KLNWASHIYPG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N37S, R41K, I64V, V77I |
| >3386-2073| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |