Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-2826 | 2826-3900 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ IDV | 20 |
| 2 | NFV+ NVP+ D4T | 49 |
| 3 | NFV+ NVP+ D4T+ RTV+ DDI+ SQV+ 3TC | 3 |
| 4 | RTV+ DDI+ SQV+ 3TC | 8 |
| 5 | DDI+ SQV+ 3TC | 4 |
| 6 | SQV+ 3TC | 1 |
| 7 | 3TC | 32 |
| 8 | RTV+ 3TC+ SQV+ DDI | 13 |
| 9 | 3TC+ SQV+ DDI | 1 |
| 10 | SQV+ DDI | 3 |
| 11 | DDI | 4 |
| 12 | APV+ ABC+ 3TC+ AZT | 8 |
| 13 | ABC+ 3TC+ AZT | 26 |
| 14 | ABC+ 3TC+ AZT+ RTV+ APV | 17 |
| 15 | RTV+ APV | 7 |
| 16 | APV | 2 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, L90M | G73S | L10I, I13V, N37ND, R41K, L63P, V77I |
| >2826-3900| codons 1-92 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVLEEMDLPGKWKPKIIGGIGGFIKVRQYD QIPIEICGHKAISTVLIGPTPVNIIGRNLMTQ |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210LW, T215F | K219Q | A98G | K122E, I135T, I202V, D218E, V245K |
| >2826-3900| codons 23-260 QWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNK RTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGI RYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKV EELRQHLWRWGFFTPEQKHQKEPPFLWMGYELHPDKWTVQPIKLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |