Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-2620 | 2620-4108 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 11 |
| 2 | 3TC+ AZT | 27 |
| 3 | 3TC+ D4T+ IDV | 24 |
| 4 | 3TC+ DDC+ IDV | 27 |
| 5 | RTV+ SQV | 16 |
| 6 | DDI+ NFV+ NVP | 68 |
| 7 | DDI+ NFV+ NVP | 12 |
| 8 | NFV+ NVP | 1 |
| 9 | NVP | 3 |
| 10 | D4T+ APV+ ABC | 103 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A | L33LF, F53L | L10I, K20R, M36I, L63S, I64V, E65D, A71V |
| >2620-4108| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTIFEEINLPGRWKPKIIGGIGGLIKVRQYD QISVDICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69TA_SA, L74V, Y115F, T215Y | D67A | K103KN, Y181C, G190A | V35IK, T39A, R83K, K101Q, D123E, D177E, T200R, K223Q, L228R |
| >2620-4108| codons 23-260 QWPLTEEKIKALKEICAELEKEGKISKIGPENPYNTPVFAIKKKASAKWRKVVDFRELNK KTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAFFSVPLDKEFRKYTAFTIPSINNETPGI RYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVICQYMDDLYVASDLEIGQHRRKI EELRQHLLRWGFYTPDKKHQQEPPFRWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |