Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-2224 | 2224-2572 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 222 |
| 2 | DDC | 42 |
| 3 | D4T | 12 |
| 4 | 3TC+ AZT | 32 |
| 5 | 3TC+ AZT+ SQV | 12 |
| 6 | 3TC+ AZT+ IDV | 25 |
| 7 | 3TC | 2 |
| 8 | 3TC+ NFV+ D4T | 1 |
| 9 | D4T+ NFV | 3 |
| 10 | RTV+ SQV | 22 |
| 11 | DDI+ NFV+ NVP | 11 |
| 12 | 3TC+ AZT+ IDV | 87 |
| 13 | ABC+ D4T+ APV | 1 |
| 14 | ABC+ D4T+ APV+ DDI | 1 |
| 15 | D4T+ APV+ DDI | 3 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73ST | L10I, L63P, A71V, V77I, P79PA, I93L |
| >2224-2572| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVITTVLIGATPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | D67G, K219N | K22N, E44D, S68G, K102KR, V118VI, I135T, I178M, H208Y, R211Q, V245E, A272P |
| >2224-2572| codons 21-273 VNQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPVFAIKKKGGTKWRKIVDFREL NKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSTNNETP GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVIYQYVDDLYVGSDLEIGQHRT KIEELRQYLWQWGFYTPDNKHQKEPPFLWMGYELHPDKWTVQPIELPEKDSWTVNDIQKL VGKLNWASQIYPG |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |