Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-2224 | 2224-112 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 222 |
| 2 | DDC | 42 |
| 3 | D4T | 12 |
| 4 | 3TC+ AZT | 32 |
| 5 | 3TC+ AZT+ SQV | 12 |
| 6 | 3TC+ AZT+ IDV | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, M184V, L210W, T215Y | S68G, I135T, I178M, R211Q, V245E, L264X |
| >2224-112| codons 21-271 VKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKDGTKWRKLVDFREL NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETP GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVIYQYVDDLYVGSDLEIGQHRT KIEELRQHLWQWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIELPEKDSWTVNDIQKL VGKFNWASQIY |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L63P, A71V, V77I, I93L |
| >2224-112| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |