Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-1351 | 1351-3062 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 34 |
| 2 | AZT+ DDC | 30 |
| 3 | DDC | 109 |
| 4 | DDC+ SQV | 7 |
| 5 | 3TC+ DDC+ IDV | 61 |
| 6 | 3TC+ D4T+ NFV | 28 |
| 7 | 3TC+ DDI+ NVP+ RTV | 12 |
| 8 | 3TC | 7 |
| 9 | 3TC+ D4T+ NFV | 66 |
| 10 | 3TC+ DDI+ APV | 5 |
| 11 | 3TC+ DDI+ APV+ D4T | 31 |
| 12 | 3TC+ APV+ D4T | 3 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54M, V82A | L10LF, K43T | M36I, L63P, A71V |
| >1351-3062| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTILEEINLPGRWTPKIIGGIGGFMKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70G, M184V, T215Y | K104KN, K122E, Q207E |
| >1351-3062| codons 30-260 KIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKNSTGWRKLVDFRELNKRTQDFWE VQLGIPHPAGLKKKNSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVL PQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELREHL LRWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |