<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
SWC-1351 1351-2904 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 34
2 AZT+ DDC 30
3 DDC 109
4 DDC+ SQV 7
5 3TC+ DDC+ IDV 61
6 3TC+ D4T+ NFV 28
7 3TC+ DDI+ NVP+ RTV 12
8 3TC 7
9 3TC+ D4T+ NFV 66
10 3TC+ DDI+ APV 5
11 3TC+ DDI+ APV+ D4T 27

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I54IM, V82A K43T M36I, L63P, A71V  
>1351-2904| codons 1-98
PQITLWQRPLVTIKIGGQLKEALLDTGADDTILEEINLPGRWTPKIIGGIGGFMKVRQYD
QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLN

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70G, M184V, T215Y   G190GA   V35VA, K122E, Q207E  
>1351-2904| codons 21-260
VKQWPLTEEKIKALAEICTEMEKEGKISKIGPENPYNTPVFAIKKKNSTGWRKLVDFREL
NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETP
GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIGQHRT
KIEELREHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005