Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-0958 | 0958-2850 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | AZT+ DDC | 39 |
| 3 | 3TC | 71 |
| 4 | 3TC+ D4T+ DLV+ IDV | 40 |
| 5 | 3TC | 3 |
| 6 | DDI+ NFV+ NVP | 45 |
| 7 | NVP | 1 |
| 8 | ABC+ EFV+ 3TC | 19 |
| 9 | APV+ DLV+ D4T | 32 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54M, L90M | T12S, K20I, E35D, M36I, I62V, L63P, A71AV, I72L |
| >0958-2850| codons 1-99 PQITLWQRPLVSIKIGGQLIEALLDTGADDTVLEDINLPGRWKPKLIGGIGGFMKVRQYD QVPIEICGHKVLGTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K103N | S68G, I135T, I178M, R211K, L228H, A272P |
| >0958-2850| codons 21-273 VKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKDGTKWRKLVDFREL NKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETP GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVIYQYMDDLYVGSDLEIGQHRT KIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL VGKLNWASQIYPG |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |