<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
SWC-0503 0503-3925 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 82
2 NRTI 132
3 AZT+ DDC 20
4 AZT+ DDI 9
5 3TC+ AZT+ RTV 60
6 3TC+ D4T+ SQV 8
7 3TC+ IDV+ NVP 66
8 3TC+ AZT+ NFV 48
9 NFV 4
10 EFV+ ABC+ APV+ RTV 3
11 EFV+ ABC+ APV+ RTV+ D4T 34
12 EFV+ ABC+ APV+ RTV+ D4T+ 3TC+ AZT 3
13 ABC+ APV+ RTV+ 3TC+ AZT 2
14 3TC+ AZT 10
15 3TC+ AZT+ APV+ RTV+ ABC 28
16 3TC+ AZT+ ABC 2
17 ABC 3

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54LV, I84V, L90M   L10I, K20R, E35D, M36I, N37S, R41K, D60E, I62V, L63P, A71IT, V77I  
>0503-3925| codons 1-92
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDISLPGKWKPKMIGGIGGFVKVRQYE
QVPIEICGHKTIGTVLIGPTPVNVIGRNLMTQ

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y     A98G V35I, K43E, E44D, V60I, V118I, K122E, E203D, D218E  
>0503-3925| codons 21-260
VKQWPLTEEKIKALIEICTELEEDGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFREL
NKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETP
GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRT
KIDELRQHLWRWGFYTPEKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005