Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-0503 | 0503-3925 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 82 |
| 2 | NRTI | 132 |
| 3 | AZT+ DDC | 20 |
| 4 | AZT+ DDI | 9 |
| 5 | 3TC+ AZT+ RTV | 60 |
| 6 | 3TC+ D4T+ SQV | 8 |
| 7 | 3TC+ IDV+ NVP | 66 |
| 8 | 3TC+ AZT+ NFV | 48 |
| 9 | NFV | 4 |
| 10 | EFV+ ABC+ APV+ RTV | 3 |
| 11 | EFV+ ABC+ APV+ RTV+ D4T | 34 |
| 12 | EFV+ ABC+ APV+ RTV+ D4T+ 3TC+ AZT | 3 |
| 13 | ABC+ APV+ RTV+ 3TC+ AZT | 2 |
| 14 | 3TC+ AZT | 10 |
| 15 | 3TC+ AZT+ APV+ RTV+ ABC | 28 |
| 16 | 3TC+ AZT+ ABC | 2 |
| 17 | ABC | 3 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54LV, I84V, L90M | L10I, K20R, E35D, M36I, N37S, R41K, D60E, I62V, L63P, A71IT, V77I |
| >0503-3925| codons 1-92 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDISLPGKWKPKMIGGIGGFVKVRQYE QVPIEICGHKTIGTVLIGPTPVNVIGRNLMTQ |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | A98G | V35I, K43E, E44D, V60I, V118I, K122E, E203D, D218E |
| >0503-3925| codons 21-260 VKQWPLTEEKIKALIEICTELEEDGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFREL NKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETP GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRT KIDELRQHLWRWGFYTPEKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |