Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-0503 | 0503-2964 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 82 |
| 2 | NRTI | 132 |
| 3 | AZT+ DDC | 20 |
| 4 | AZT+ DDI | 9 |
| 5 | 3TC+ AZT+ RTV | 60 |
| 6 | 3TC+ D4T+ SQV | 8 |
| 7 | 3TC+ IDV+ NVP | 66 |
| 8 | 3TC+ AZT+ NFV | 48 |
| 9 | NFV | 4 |
| 10 | EFV+ ABC+ APV+ RTV | 3 |
| 11 | EFV+ ABC+ APV+ RTV+ D4T | 30 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T215Y | K103N | A98G | V35I, K43E, V60I, R83K, K122E, D218E |
| >0503-2964| codons 21-260 VKQWPLTEEKIKALIEICTELEEEGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFREL NKKTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETP GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRT KIEELRQHLLRWGFYTPEKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10I, K20R, E35D, M36I, N37S, R41K, D60E, I62V, L63P, A71T, V77I, Q92X, I93L |
| >0503-2964| codons 1-94 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDISLPGKWKPKMIGGIGGFVKVRQYE QVPIEICGHKTIGTVLIGPTPVNVIGRNLMTHLG |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |