Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-0211 | 0211-3134 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 39 |
| 2 | AZT+ DDC | 17 |
| 3 | D4T | 21 |
| 4 | 3TC+ D4T+ IDV | 126 |
| 5 | D4T | 1 |
| 6 | D4T+ DDI+ NFV | 45 |
| 7 | D4T+ NFV | 1 |
| 8 | D4T | 3 |
| 9 | D4T+ ABC+ APV+ 3TC | 4 |
| 10 | D4T+ APV+ 3TC | 11 |
| 11 | D4T+ APV+ 3TC | 10 |
| 12 | D4T+ APV+ 3TC | 20 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | A33S, V35L, T39A, E40F, K43E, V118I, K122E, Q207E, H208Y, R211K, V245E |
| >0211-3134| codons 32-260 KSLLEICAFLEEEGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQ LGIPHPAGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQ GWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELREYLWK WGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIELPEKDSWTVNDIQKL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, L33F | L10I, K20R, M36I, I62V, L63P, I66F, A71V |
| >0211-3134| codons 1-99 PQITLWQRPIVTIKIGGQLREALIDTGADDTVFEEINLPGRWKPKLIGGIGGFVKVRQYD QVPIEFCGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |