Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 89M2626 | 89M2626 | U.K. | 2001 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 261 |
| 2 | SQV+ 3TC+ D4T | 108 |
| 3 | DDC+ NFV+ NVP | 17 |
| 4 | RTV+ DDI+ D4T+ SQV | 47 |
| 5 | SQV+ RTV+ DDI+ AZT | 89 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | T215I, K219E | K103N | L234LI | E6D, V35T, T39M, V60I, K122E, D123S, I135T, K173S, Q174K, V179IT, T200A, Q207A, R211S, D218DE, T286A, E291D, I293V, P294T, I329V |
| >89M2626| codons 1-335 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICMEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPDIII YQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGFITPEEKHQKEPPFLWMGYEIHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | F53L, L89V | L10I, I13V, K14R, K20I, E35D, M36I, N37E, R41K, R57K, H69K, A71V, T74S |
| >89M2626| codons 1-99 PQITLWQRPIVTVRIGGQLIEALLDTGADDTVLEDIELPGKWKPKMIGGIGGLVKVKQYD QILIEICGKKVIGSVLVGPTPVNIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Weber, J | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |