Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| M41971 | M41971 | U.K. | 2001 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 65 |
| 2 | None | 71 |
| 3 | 3TC+ AZT | 58 |
| 4 | AZT+ IDV+ 3TC | 44 |
| 5 | None | 73 |
| 6 | NVP+ NFV+ LPV | 102 |
| 7 | LPV+ NVP+ 3TC | 35 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, M184V, T215F | K219Q | Y181I | E6D, T27S, V35T, T39A, V60I, K122E, D123S, I135T, E138A, I142IV, K173A, Q174K, V179I, Q207A, F214L, D218E, L228LH, V245M, D250DE, A272P, T286A, A288T, I293V, P294T |
| >M41971| codons 1-334 PISPIDTVPVKLKPGMDGPKVKQWPLSEEKIKALTEICAELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNATPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPDIII IQYVDDLYVGSDLEIGQHRTKIEELRAHLLRWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPIMLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKTLTEVVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L10F, L33I | T4TS, I13V, G16E, L19LI, K20R, E35D, M36I, N37D, R41K, K45V, K55T, R57K, L63H, H69K, K70R, L89M, T91TS |
| >M41971| codons 1-99 PQISLWQRPFVTVKIEGQIREALLDTGADDTVIEDIDLPGKWKPVMIGGIGGFVTVKQYD QIHIEICGKRAIGTVLVGPTPANIIGRNMLSQIGCTLNF |
References
| Author | Title | Citation |
| Weber, J | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |