<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
M46228 M46228 U.K. 2002 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 D4T+ DDI+ NVP 69
2 AZT+ 3TC+ NVP 74

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K32R, V35AE, E36A, T39E, S48T, K122E, D123N, I135T, E138A, K173I, G196K, T200A, Q207E, R211K, V245Q, E248D, A272P, K275R, K277R, Q278H, T286A, E291D, V292I, I293V, V317A, D324E  
>M46228| codons 1-324
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIRALAAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIQNPDIVI
YQYMDDLYVGSDLEIKQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIRVRHLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGAYYDPSKE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, G16A, L19T, K20R, M36I, R41K, D60E, Q61QE, L63P, H69K, V77I, L89M, I93L  
>M46228| codons 1-99
PQITLWQRPLVSIKIAGQTREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYE
EIPIEICGKKAIGTVLIGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Weber, J Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005