Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| F16446 | F16446 | U.K. | 2002 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 95 |
| 2 | D4T+ 3TC+ SQV | 41 |
| 3 | NVP+ NFV+ DDI | 54 |
| 4 | DDI+ NFV+ ABC | 65 |
| 5 | NVP+ AZT+ 3TC | 48 |
| 6 | APV+ LPV+ 3TC | 48 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184V, T215Y | K219KQ | Y188L | V35T, T39E, S48T, K64KR, K122E, E138S, V148VG, S162C, K173T, Q174K, D177E, I178L, V179I, G196E, T200A, Q207D, R211K, D237N, V245Q, D250E, I257L, A272S, K281R, E291D, V292I, I293V, E297EK, H315Y |
| >F16446| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPV FAIRKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNSTPGIRYQYNGLPQGWKGSPAIFQCSMTKILEPFRTKNPELII YQYVDDLLVGSDLEIEQHRAKIEELRDHLLKWGFYTPDQKHQKEPPFLWMGYELHPNKWT VQPIQLPEKESWTVNDLQKLVGKLNWASQIYSGIKVKQLCRLLRGTKALTDIVPLTKEAE LELAENREILKEPVYGVYYDPSKDLIAEIQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10I, T12S, L19I, K20M, M36I, R41K, D60E, L63P, H69K, L89M, I93L |
| >F16446| codons 1-99 PQITLWQRPIVSIKIGGQIMEALLDTGADDTVLEEINLPGKWKPKIIGGIGGFVKVRQYE QIPIEICGKKAIGTVLVGPTPVNVIGRNMMTQLGCTLNF |
References
| Author | Title | Citation |
| Weber, J | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |