Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| F46097 | F46097 | U.K. | 2001 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 80 |
| 2 | D4T+ 3TC | 62 |
| 3 | NFV+ DDI+ D4T | 35 |
| 4 | NFV+ DDI+ D4T+ NVP | 35 |
| 5 | NVP+ DDI+ D4T+ SQV+ RTV | 78 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T4TP, I13V, K14R, Q18QH, E35D, M36I, R41K, R57K, L63P, H69K, L89M |
| >F46097| codons 1-99 PQIPLWQRPLVTVRIGGHLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103KN | E6D, V35T, K49R, V60I, K122E, D123S, I135T, S162X, E169D, K173A, Q174K, D177E, I178L, T200A, Q207A, R211S, F214L, V245Q, D250E, A272P, K281R, R284RK, T286A, V292VL, I293V, P294PT, H315Q, V317I |
| >F46097| codons 1-317 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQXSMTKILDPFRAKNPELVI YQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLKGAKALTELVTLTEEAE LELAENREILKEPVQGI |
References
| Author | Title | Citation |
| Weber, J | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |