Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| M62717 | M62717 | U.K. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 54 |
| 2 | IDV+ 3TC+ D4T | 49 |
| 3 | 3TC+ D4T+ NVP+ SQV+ RTV | 66 |
| 4 | ABC+ DDI+ D4T | 110 |
| 5 | 3TC+ ABC+ LPV | 27 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67HN, K70R, L74V, M184V, T215F | K219E | K103N | I5IV, V35T, K43R, I50V, A98S, K122E, D123S, P170PS, Q174QR, D177DN, Y181X, R211K, F214FL, D218E, A272P, K277R, V292I, E297K, I326IL, I329IL |
| >M62717| codons 1-335 PISPVETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEREGKISKVGPENPYNTPV FAIKKKHSTRWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILESFRKRNPNIVI XQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGLFTPEEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIIPLTKEAE LELAENREILKEPVHGVYYDPSKDLLAELQKQGQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | I13AV, K14R, I15IV, K20IV, L24X, E35D, M36I, N37D, R41K, K45V, L63LP, I64IV, H69K, V82I, L89I, Q92QK |
| >M62717| codons 1-99 PQITLWQRPLVTARVGGQLIEALXDTGADDTVLEDIDLPGKWKPVMIGGIGGFVKVRQYD QIPVEICGKKAIGTVLVGPTPINVIGRNIMTKIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Weber, J | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |