<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
F45753 F45753 U.K. 2002 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 AZT 28
2 SQV+ 3TC+ D4T 92
3 NFV+ DDI+ D4T 166
4 3TC+ AZT+ ABC 55

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y       K11T, K20R, V21I, V35T, T39S, E44ED, V60I, D121H, K122E, D123S, D177E, V179I, T200A, I202V, Q207A, V245K, D250E, S251H, T286A, E291D, V292I, I293V, P294T, E312D  
>F45753| codons 1-334
PISPIETVPVTLKPGMDGPRIKQWPLTEEKIKALTEICSELEKDGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
HESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII
YQYVDDLYVGSDLEIGQHRAKVEELRAHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKEHWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAE
LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQ

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, I13V, G16E, K20R, E35D, M36I, P39S, R41K, H69K, L89M  
>F45753| codons 1-99
PQITLWQRPIVTVKIEGQLREALLDTGADDTVLEDINLSGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Weber, J Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005