Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-7873 | 7873-3061 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV+ 3TC+ D4T | 1 |
| 2 | 3TC+ D4T | 11 |
| 3 | IDV | 12 |
| 4 | IDV+ D4T+ 3TC | 11 |
| 5 | D4T+ 3TC | 42 |
| 6 | D4T+ 3TC+ IDV | 34 |
| 7 | 3TC+ IDV | 9 |
| 8 | 3TC+ IDV+ D4T | 11 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, V82A | L63P, A71V |
| >7873-3061| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTILEEMNLPGRWKPKLIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | T39A, K104KT, A158S, P176S |
| >7873-3061| codons 23-260 QWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNK RTQDFWEVQLGIPHPAGLKKKTSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGI RYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNSDIVIYQYVDDLYVGSDLEIGQHRTKI EELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |