Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-7353 | 7353-2381 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NVP+ D4T | 1 |
| 2 | D4T | 1 |
| 3 | D4T+ NFV | 4 |
| 4 | D4T+ NFV+ DLV | 91 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | E35D, M36V, N37H, R41K, L63P, I64V, K70R, V77I |
| >7353-2381| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADNTVLEDVHLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHRAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215Y | Y181C | S68G, K102E, A158S |
| >7353-2381| codons 41-263 MEKEGKISKIGPENPYNTPVFAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGL KEKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIF QSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDKK HQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGK |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |