Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-5573 | 5573-2632 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | NFV | 10 |
| 3 | NFV+ 3TC+ D4T | 27 |
| 4 | NFV+ 3TC+ AZT | 72 |
| 5 | 3TC+AZT+NFV | 8 |
| 6 | 3TC+AZT+NVP | 1 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, I15V, L63H |
| >5573-2632| codons 1-99 PQITLWQRPLVTVKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIHIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | A62AV | K103N | V90VI, K122E, I135T, S162C, Q174K, R211KT, V245E, A272P |
| >5573-2632| codons 23-273 QWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFVIKKKDSTKWRKLVDFRELNK RTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGI RYQYNVLPQGWKGSPAIFQCSMTKILEPFRKKNPDIVIYQYVDDLYVGSDLEIGQHRTKI EELRQHLLTWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIELPEKDSWTVNDIQKLVG KLNWASQIYPG |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |