Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-3496 | 3496-2173 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T | 4 |
| 2 | D4T+ 3TC | 23 |
| 3 | NVP+ DDI+ NFV | 28 |
| 4 | DDI+ NFV | 1 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30DN, I54IL | N88D | N37S, R41RK, L63P, I64IL | W6W* |
| >3496-2173| codons 1-99 PQITL*QRPLVTIKIGGQLKEALLDTGADNTVLEEMSLPGKWKPKMIGGIGGFLKVRQYD QIPLEICGHKAIGTVLVGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, L74I, M184V, T215F | K219Q | G190A | D123E, S162D, I178M, V179I, Q207E, F214L, V245K, L260I |
| >3496-2173| codons 31-260 IKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKIVDFRELNKRTQDFWEV QLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLP QGWKGSPAIFQDSMTKILEPFRKQNPDMIIYQYVDDLYVASDLEIGQHRTKIEELREHLL RWGLFTPDQKHQKEPPFLWMGYELHPDKWTVQPIKLPEKDSWTVNDIQKI |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |