Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-1133 | 1133-4246 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV+ 3TC | 1 |
| 2 | IDV+ 3TC+ D4T | 105 |
| 3 | ABC+ APV+ DDI | 33 |
| 4 | ABC+ APV+ DDI+ RTV | 34 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IM | L10I, N37D, K43R, L63P, V77I |
| >1133-4246| codons 1-91 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWRPKIIGGIGGFMKVRQYD QIPIEICGHKAIGTVLIGPTPVNIIGRNLLT |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, M184V | R83K, K173R, Q174K, Q207E, R211K, I257L |
| >1133-4246| codons 21-260 VKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFREL NKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETP GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPDIVIYQYVDDLYVGSDLEIGQHRT KIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDLQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |