Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-0437 | 0437-4236 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT | 1 |
| 2 | 3TC+ AZT+ SQV | 86 |
| 3 | 3TC+ AZT | 15 |
| 4 | 3TC+ AZT+ EFV | 43 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I13V, L19I, M36I, L63P, V82I |
| >0437-4236| codons 1-93 PQITLWQRPLVSVKIGGQIKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPINIIGRNLLTQI |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K103NS, G190A | V35I, V60I, T69N, I132V, I135L |
| >0437-4236| codons 30-260 KIKALIEICTEMEKEGKISKIGPENPYNTPIFAIKKKDSNKWRKLVDFRELNKRTQDFWE VQLGIPHPAGLKKSKSVTVLDVGDAYFSVPLDKDFRKYTAFTVPSLNNETPGIRYQYNVL PQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIGQHRTKIEELRQHL LRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |