Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-0045 | 0045-3869 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC | 9 |
| 2 | 3TC | 3 |
| 3 | 3TC+ IDV+ D4T | 94 |
| 4 | 3TC+ D4T | 1 |
| 5 | 3TC+ D4T+ NFV | 66 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | T12P, I13V, M36I, L63P, A71V |
| >0045-3869| codons 1-92 PQITLWQRPLVPVKIGGQLKEALLDTGADNTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPVNIIGRNLLTQ |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | E40ED, V60I, R83K, D123E, I135T, D177E, V245K |
| >0045-3869| codons 21-260 VKQWPLTEEKIKALVEICTDMEKEGKISKIGPENPYNTPIFAIKKKDSTKWRKLVDFREL NKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSTNNETP GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIGQHRT KIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIKLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |