Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 99ZACM4 | 99ZACM4 | South Africa | 1999 | HIV1 | C | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K20I, E35D, M36I, N37S, R41K, I64M, K70R, L89M |
| >99ZACM4| codons 1-99 PQITLWQRPLVTVKIGGQLIEALLDTGADDTVLEDISLPGKWKPKMIGGIGGFIKVRQYD QILMEICGHRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39E, S48T, V90I, K173A, Q174K, D177E, T200A, Q207A, R211K, V245Q, A272P, K275R, T286A, E291D, V292I, I293V, P294L, A327V, Q334H, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, V435A, R461K, S468N, D471E, H483Q, L491P, K512R, S519N, A534S, A554S | Q278G |
| >99ZACM4| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKGLCKLLRGAKALTDIVLLTEEAE LELAENREILKEPVHGVYYDPSKDLIVEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRRTA HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTDKGRQKVVNLTETTNQKTELQ AIQLALQDSGPEVNIVTDSQYALGIIQAQPDRSESELVNQIIEQLIKKEKVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E11D, S17C, V31I, L101I, T112V, I113V, T124A, T125A, G134N, T206S, N222K, L234I | S283G |
| >99ZACM4| codons 1-288 FLDGIDKAQEDHEKYHCNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVVHTDNGSN FTSAAVKAACWWANIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIVDIIASDIQTKELQKQITKIQKFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED |
References
| Author | Title | Citation |
| Papathanasopoulos, MA | Full-length genome analysis of HIV-1 subtype C utilizing CXCR4 and intersubtype recombinants isolated in South Africa. | ARHR, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |