<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
99BW4754 99BW4754 Botswana 1999 HIV1 C PBMC None

Treatment History
Order Regimen Weeks
1 None NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, V118I, K122E, D123N, I135T, E138A, I142V, K173A, T200A, E204K, Q207E, F214L, V245L, D250E, A272P, K275Q, T286A, E291D, V292I, I293V, Q334N, R356K, G359T, T369A, I375V, T377I, T386I, K390R, A400T, E404D, A437V, E449D, D471E, L491P, S519N, E529K, A534S, A554S, V559I L234P
>99BW4754| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSTNNATPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEKLREHLLRWGLTTPDKKHQKEPPFLWMGYEPHPDKWT
VQPILLPEKESWTVNDIQKLVGKLNWASQIYPGIQVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLAEAVQKVAIESIVIWGKIPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGVETFYVDGAANRDTKLGKAGYVTDRGRQKVVSLTETTNQKTELQ
AIHLALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKKKVYLSWVPAHK
GIGGNEQVDKLVSSGIRKIL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19I, E35D, M36I, R41K, L63H, H69K, K70R, L89M, I93L  
>99BW4754| codons 1-99
PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QIHIEICGKRAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    G4E, E10D, D25E, S39C, L45Q, M50I, F100Y, L101I, T125A, K136Q, V201I, T206S, K211R, T218I, L234I, N254K, R269K S283G
>99BW4754| codons 1-288
FLDEIDKAQDEHEKYHSNWRAMASEFNLPPVVAKEIVACCDKCQQKGEAIHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKTIHTDNGSN
FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIASDIQTRELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDKSDIKVVPRRKAKIIKDYGKQMAGDDCVAGRQDED

References
Author Title Citation
Novitsky, V Human immunodeficiency virus type 1 subtype C molecular phylogeny: consensus sequence for an AIDS vaccine design? J Virol, 2002