<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
00BW1795 00BW1795 Botswana 2000 HIV1 C PBMC None

Treatment History
Order Regimen Weeks
1 None NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, E40D, S48T, V118I, K122E, D123G, E138A, K166R, K173T, D177E, T200A, E204K, Q207E, R211K, F214L, A272P, K277T, T286A, E291D, V292I, I293V, E297D, Q334H, G335D, R356K, M357R, G359T, T377L, T386I, K390R, A400T, E404D, I434V, V435A, A437V, L452M, V466I, V467I, D471E, T477A, Q480H, H483Q, L491P, K527N, K530R, A534S, A554S  
>00BW1795| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEDMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEGFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRTQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEKLREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVTQLCKLLRGAKALTDIVPLTDEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKIALESIVIWGKIPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPVAGVETFYVDGAANRETKMGKAGYVTDRGRQKIISLTETTNQKAELH
AIQLALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLINKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19I, E35D, M36I, R41K, Q61H, L63P, H69K, K70R, L89M, I93L T96I
>00BW1795| codons 1-99
PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
HIPIEICGKRAIGTVLVGPTPVNIIGRNMLTQLGCILNF

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    S24N, D25E, V31I, M50I, I73V, I84L, A91T, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, K211R, T218I, S230N, L234I, I251L, D256E, A265V, D278A S283G
>00BW1795| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMANEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIVLVAVHVASGYLEAEVIPTETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTRELQKQIIKIQNFRVYYRDNRDPIWKGPAK
LLWKGEGAVVLQDNSEIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED

References
Author Title Citation
Novitsky, V Human immunodeficiency virus type 1 subtype C molecular phylogeny: consensus sequence for an AIDS vaccine design? J Virol, 2002