Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1293 | CA3220 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 52 |
| 2 | 3TC+D4T | 52 |
| 3 | 3TC+D4T+IDV | 52 |
| 4 | 3TC+D4T+NFV+NVP | 48 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | Y181C | V108VI, V179E | V35I, K43Q, A98S, K102Q, D121Y, K122E, I135T, T200A, K223Q, L228R, V245M, A272P, K275R, K277R, P294T |
| >CA3220| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKQKKSVTILDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIEI CQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDKKHQQEPPFRWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVITLTEEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A | L24I, L89V | L10I, I15V, N37X, Q61E, I62V, L63P, I64M, I93L |
| >CA3221| codons 1-99 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEEMXLPGRWKPKLIGGIGGFIKVRQYD EVPMEICGHKAIGTVLVGPTPANIIGRNVLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Colinearity of reverse transcriptase inhibitor resistance mutations detected by population-based sequencing. | JAIDS, 2003 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |