Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1290 | CA3215 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 22 |
| 2 | D4T | 35 |
| 3 | 3TC+AZT+SQV | 13 |
| 4 | 3TC+AZT+IDV | 48 |
| 5 | 3TC+AZT+DDI+NFV+NVP | 18 |
| 6 | 3TC+AZT+IDV | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A, L90M | G73T | L10I, I15V, M36I, N37D, K45R, L63P, H69K, I93L |
| >CA3215| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEIDLPGRWKPRIIGGIGGFIKVRQYD QIPIEICGKKAITTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215F | K219Q | K103N | K122E, I178M, T200A, Q207E, D218E, K223KR, D250A, A272P, E297A | R172RS |
| >CA3214| codons 1-298 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFSKQNPDMVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGFFTPEQKHQREPPFLWMGYELHPDKWT VQPIVLPEKASWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTAE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |