Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1289 | CA3211 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 4 |
| 2 | D4T | 17 |
| 3 | 3TC+D4T | 9 |
| 4 | 3TC+D4T+SQV | 48 |
| 5 | 3TC+D4T+NFV | 25 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N88S, L90M | K43T | R57K, I62V, L63P, A71X |
| >CA3211| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWTPKMIGGIGGFIKVKQYD QVPIEICGHKXIGTVLVGPTPVNIIGRSLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K20R, V35I, I135V, I142V, T165I, K201KI, K219X, K238KR | E53E*, K220KN |
| >CA3210| codons 1-274 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTEMEKEGKISKIGP*NPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTIIEELRQHLLRWGFTTPDXNHQKEPPFLWMGYELHPDRWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGI |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |