Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| A116 | AF357830 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 52 |
| 2 | NVP+ RTV+ D4T | 47 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R | K103N, Y181C | T69N, A98S, D123E, T139K, Q174H, D177E, T200A, R211K, P243T, V276T, K281R, T286TA, E297K |
| >AF357830| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSNRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPEIVI CQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQTIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKTKQLCRLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A | L63P, A71AT, V77I |
| >AF357830| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKTIGTVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Eshleman, SH | Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir (Pediatric AIDS Clinical Trials Group 377). | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |