Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1137 | CA3203 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | None | 31 |
| 3 | DDC | 135 |
| 4 | D4T | 22 |
| 5 | D4T+DDI | 17 |
| 6 | 3TC+D4T+SQV | 26 |
| 7 | 3TC+AZT+IDV | 26 |
| 8 | 3TC+AZT | 22 |
| 9 | 3TC+AZT+RTV+SQV | 9 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | T39A, K43KQ, R83K, V90I, S162Y |
| >CA3203| codons 1-258 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEQEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, V82VAIT, L90LM | L10LF, F53FL, G73GS | M36MI, G51GA, I62IV, L63P, A71V, I93IL |
| >CA3204| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEINLPGRWKPKIIGGIAGLIKVRQYD QVPIEICGHKVISTVLVGPTPANIIGRNLMTQMGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing. | AAC, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |