Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA626 | CA3200 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 122 |
| 2 | DDI | 57 |
| 3 | D4T | 52 |
| 4 | 3TC+D4T | 13 |
| 5 | 3TC+D4T+SQV | 43 |
| 6 | 3TC+D4T+NFV | 11 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70G, Q151M, M184V | D67G, F77L, F116Y | I31X, S68N, Q207E, F214L, T286A |
| >CA3200| codons 1-298 PISPIETVPVKLKPGMDGPKVKQWPLTEEKXKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKGNTGWRKLVDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTEE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | N37S, R57K, L63P, A71T |
| >CA3201| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKTIGTVLVGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |