Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA606 | CA3198 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 209 |
| 2 | DDI | 82 |
| 3 | D4T | 39 |
| 4 | 3TC+AZT | 17 |
| 5 | 3TC+AZT+SQV | 9 |
| 6 | 3TC+AZT+IDV | 57 |
| 7 | 3TC+D4T+RTV+SQV | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | G73S | L10I, K20IM, N37ND, I62V, L63P, K70R, A71AITV, I72IL |
| >CA3198| codons 1-99 PQITLWQRPIVTIKIGGQLMEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHRVLSTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K20R, A98S, K102KR, K122E, A158S, Q197E, L228LH, V245X, A272P, L283I, I293V |
| >CA3199| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKRKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGEHRTKIEELRQHLLRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIXLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTEEAE LEL |
References
| Author | Title | Citation |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |