Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1123 | CA3194 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 29 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A, L90M | M36I, R41K, K43KN, K45R, I62V, L63P, A71T |
| >CA3194| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEINLPGKWNPRMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184V, T215F | K219Q | T27X, I31L, V35M, T39TP, K64KR, D121X, K122E, E169D, D177E, I202V, R211K, K277R, T286X, P294S |
| >CA3193| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLXEEKLKALMEICPEMEKEGKISKIGPENPYNTPV FAIRKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL XEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGXKALTEVISLTEEAE LE |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |