Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA622 | CA3188 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 18 |
| 2 | AZT+DDC | 4 |
| 3 | AZT+DDI | 13 |
| 4 | 3TC+AZT | 44 |
| 5 | 3TC+D4T+IDV | 22 |
| 6 | D4T+DDI+IDV | 30 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | V75VA, K219E | V35I, E44D, V118I, K122E, I202V, H208Y, R211K, L228H, I257L, I293V, E297K |
| >CA3188| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKLADFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKVEELRQYLWKWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDLQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82T, L90M | G73S | L10I, R41K, K43KN, K45R, L63P, A71V, V77I, I85V, I93L |
| >CA3189| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWNPRIIGGIGGFIKVRQYD QIPIEICGHKVISTVLIGPTPTNIVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |