Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| A068 | AF357817 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 52 |
| 2 | NFV+ NVP+ D4T | 48 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75T, L210W, T215Y | A62AV | Y181C | K20R, K49R, K64R, D123E, I142V, D177E, I178L, E203K, Q207E, R211K, K223E, V241VM, T286A, E297K |
| >AF357817| codons 1-324 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISRIGPENPYNTPV FVIRKKNSDKWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELVI CQYMDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPDKKHQEEPPFLWMGYELHPDKWT MQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46ML | N88ND | I13IV, K20KR, E35D, M36I, N37D, R41K, K45KQ, L63P, K70R |
| >AF357817| codons 1-99 PQITLWQRPLVTVKIGGQLREALLDTGADNTVLEDIDLPGKWKPQLIGGIGGFIKVRQYD QIPIEICGHRAIGTVLVGPTPVNIIGRDLLTQIGCTLNF |
References
| Author | Title | Citation |
| Eshleman, SH | Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir (Pediatric AIDS Clinical Trials Group 377). | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |