Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| A056 | AF357812 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 52 |
| 2 | 3TC+ NFV+ D4T | 21 |
| 3 | None | 3 |
| 4 | NFV | 4 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | E6D, V35EK, Y144YF, M164ML, I178M, V179I, Q197K, T200TI, R211K, A272P, K281KR, P294T, E297K | L168LF, P217R |
| >AF357812| codons 1-324 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALEEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRFQYNVLPQGWKGSPAIFQSSLTKIFEPFRKQNPDMII YQYVDDLYVGSDLEIGKHRIKIEELRQHLLKWGFTTRDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVITLTKEAE LELAENREILKEPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M36MI, N37A, I62V, L63LP |
| >AF357812| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEIALPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Eshleman, SH | Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir (Pediatric AIDS Clinical Trials Group 377). | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |