Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| A043 | AF357645 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 52 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, V75T | K219Q | K64R, V106VI, V118I, K122KT, D123E, I142T, D177E, I178M, R211K, F214L, L228H, V245VM, E248ED, D250DE, E291D, E297K | G18C |
| >AF357645| codons 1-324 PISPIETVPVKLKPGMDCPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIRKKDSTKWRKVTDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DTEFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGLTTPDQKHQKEPPFHWMGYELHPDKWT VQPIMLPDKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDVIPLTKEAE LELAENREILKEPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, L63R, K70E, V77I |
| >AF357645| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIRIEICGHEAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Eshleman, SH | Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir (Pediatric AIDS Clinical Trials Group 377). | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |