Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA605 | CA3175 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 330 |
| 2 | 3TC+AZT | 22 |
| 3 | 3TC+AZT+IDV | 35 |
| 4 | 3TC+D4T+IDV | 13 |
| 5 | 3TC+D4T+IDV+NVP | 17 |
| 6 | 3TC+D4T+RTV+SQV | 3 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, M184V, L210W, T215F | K219Q | Y181C | K20R, K43KE, V60I, D121Y, K122E, I135M, S162F, D177E, G196E, H208Y, R211K, D218DE, L228H |
| >CA3175| codons 1-277 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPI FAIKKKNSDRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQFSMTKILEPFRKQNPEIVI CQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73CS | L10I, L63P, V77I, I93L |
| >CA3176| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKAICTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |