Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| A012 | AF357740 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 52 |
| 2 | NVP+ RTV+ D4T | 36 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215Y | G190A | T39S, S68SR, T69S, R83K, G196E, Q207H, R211K, V245M, R284K, K311R | N54NK |
| >AF357740| codons 33-324 ALVEICSEMEKEGKISKIGPEKPYNTPVFAIKKKDRSKWRKLVDFRELNKKTQDFWEVQL GIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQG WKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVASDLEIEQHRTKIEELRHHLLKW GFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIMLPEKDSWTVNDIQKLVGKLNWASQIYA GIKVKQLCKLLKGTKALTEVIPLTEEAELELAENREILREPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15L, L63P, K70R, A71V, V77I, I93L, L97X, F99X |
| >AF357740| codons 1-99 PQITLWQRPLVTIKLGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHRVIGTVLIGPTPVNIIGRNLLTQLGCTXNX |
References
| Author | Title | Citation |
| Eshleman, SH | Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir (Pediatric AIDS Clinical Trials Group 377). | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |