<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
A012 AF357740 U.S. 1998 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ DDI 52
2 NVP+ RTV+ D4T 36

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
T215Y   G190A   T39S, S68SR, T69S, R83K, G196E, Q207H, R211K, V245M, R284K, K311R N54NK
>AF357740| codons 33-324
ALVEICSEMEKEGKISKIGPEKPYNTPVFAIKKKDRSKWRKLVDFRELNKKTQDFWEVQL
GIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQG
WKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVASDLEIEQHRTKIEELRHHLLKW
GFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIMLPEKDSWTVNDIQKLVGKLNWASQIYA
GIKVKQLCKLLKGTKALTEVIPLTEEAELELAENREILREPVHGVYYDPSKD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15L, L63P, K70R, A71V, V77I, I93L, L97X, F99X  
>AF357740| codons 1-99
PQITLWQRPLVTIKLGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHRVIGTVLIGPTPVNIIGRNLLTQLGCTXNX

References
Author Title Citation
Eshleman, SH Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir (Pediatric AIDS Clinical Trials Group 377). J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005