Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA635 | CA3142 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 21 |
| 2 | AZT+DDC | 35 |
| 3 | 3TC+AZT | 31 |
| 4 | 3TC+AZT+D4T | 13 |
| 5 | 3TC+AZT+IDV | 4 |
| 6 | D4T+DDI+SQV | 39 |
| 7 | D4T+DDI+RTV+SQV | 1 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V | L10LF, I47IL, G73S | E34D, M36I, R41RS, K43KN, I62V, L63P, A71AV, I93L |
| >CA3142| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLDEINLPGSWNPKMLGGIGGFIKVRQYD QVPIEICGHKVISTVLVGPTPVNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184MV, T215F | K219Q | A98G | K64KR, D123E, I135T, Q207K, F214L, T286A, K287R |
| >CA3141| codons 1-292 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIRKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRKHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGARALTEV |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |