<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PL9728 60099 Portugal 2001 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 IDV+ DDI+ D4T NA
2 ATV+ RTV+ IDV+ DDC+ AZT NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A L33I, F53L, N83D L10Y, I13V, G16E, K20R, A22AV, E35DN, M36I, N37ND, R41RK, L63T, H69K, T74S, L89M, T91A  
>60099| codons 1-99
PQITLWQRPYVTVKIEGQLREVLLDTGADDTVIEDIDLPGKWKPKMIGGIGGLVKVRQYD
QITIEICGKKAIGSVLVGPTPADIIGRNMLAQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y       V35T, K43KE, V118VI, D121H, K122E, I135T, I142V, K173S, Q174K, D177E, T200A, Q207A, R211K, V245K, K281R, T286A, E291D, V292I, I293V, E297K, A304E, E312N, D320E, D324E, I329V  
>60099| codons 1-332
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEEEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
HEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELRAHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDIVPLTKEAE
LELEENREILKNPVHGVYYEPSKELIAEVQKQ

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005