Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA641 | CA3114 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | AZT+DDI | 117 |
| 3 | 3TC+AZT | 31 |
| 4 | 3TC+AZT+IDV | 26 |
| 5 | 3TC+D4T+IDV | 27 |
| 6 | 3TC+D4T+RTV+SQV | 3 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, T69AD, M184V, L210W, T215Y | K20KR, V35M, T39S, K43E, E44D, V111VI, V118I, K122E, T200A, E203K, Q207D, H208Y, R211K, K223E, L228HR, A272P, K277R |
| >CA3114| codons 1-278 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICSELEEDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDIGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIKELRDYLWKWGFYTPDKKHQEEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, V82VA | L33IV | L10I, N37C, L63P, A71AV |
| >CA3113| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVVEEMCLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |